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KMID : 0358419930360020226
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Korean Journal of Obstetrics and Gynecology
1993 Volume.36 No. 2 p.226 ~ p.234
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Saliva and Serum CA 125 Assays for Detecting Malignant Ovarian Tumors
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남계현
전호용/차상헌/이순곤/이권해/조태호
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Abstract
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Since Bast discovered the monoclonal antibody CA 125 for ovarian cancer, use of this antibody to estimate serum CA 125 has been established as a good tumor marker for detecting ovarian malignancy & follow-up after primary surgery. CA 125 is a
glycoprotein complex that might also be found in saliva.
So, we assaied the CA 125 levels form saliva and serum of 28 normal women, 38 benign pelvic mass patients and 34 gynecologic malignant patients and determined the correlation between saliva and serum CA 125 levels.
@ES The following results were obtained.
@EN 1. The CA 125 level of saliva was significantly higher by normal saline dilution than by free serum dilution.
2. The CA 125 level of saliva in normal control women (mean±ISD: 1541±1468U/ml)was significantly lower than those of benign pelvic mass patients (2823±2314U/ml) and gynecologic malignant patients (3142±2845 U/ml).
3. The diagnostic efficiency of saliva CA 125 for detecting ovarian malignant tumors was equal to that of serum CA 125.
4. No correlation between saliva CA 125 and serum CA 125 was obseved.
5. There were many cervical cancer patients who had normal serum CA 125 levels but had high saliva CA 125 levels over normal range.
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KEYWORD
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